The predictive role of soluble programmed death ligand 1 in digestive system cancers

Introduction The prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value sPD-L1 expression DSCs. Methods Comprehensive searches were run on electronic databases (PubMed, Web Science, EMBASE, and Cochrane Library) identify studies that assessed Review Manager software (version 5.3) was used for all analyses. Pooled data survival outcomes measured as hazard ratios (HRs), 95% confidence intervals (CIs), odds their CIs. Results search identified 18 involving 2,070 patients with meta-outcome revealed a high level related poorer overall (HR, 3.06; CI: 2.22–4.22, p<0.001) disease-free 2.53; 1.67–3.83, Individually, significance highest hepatic cell carcinoma 4.76; followed by gastric cancer (HR=3.55, p<0.001). Conclusion may be factor DSCs survival. Inflammatory cytokines, treatment approaches, other factors affect sPD-L1. Therefore, recurrence metastasis should further investigated. also predict response treatment. Well-designed prospective standard assessment methods conducted determine